Why does roche state that it is naive

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We would like to thank Ferring Pharmaceuticals Aalst, Belgium for an unrestricted educational grant. This research has been conducted through collaboration with the Bimetra biobank, a high quality bio-repository for the University Hospital Ghent and the University of Ghent.

Matthias S. You can also search for this author in PubMed Google Scholar. Publisher's note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Reprints and Permissions. Comparative analysis of naive, primed and ground state pluripotency in mouse embryonic stem cells originating from the same genetic background.

Sci Rep 8, Download citation. Received : 06 December Accepted : 13 March Published : 12 April Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative.

Nature Biotechnology BMC Veterinary Research Journal of Assisted Reproduction and Genetics By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Advanced search. Skip to main content Thank you for visiting nature. Download PDF. Subjects Cell biology Embryonic stem cells. Abstract Mouse embryonic stem cells mESCs exist in a naive, primed and ground state of pluripotency.

Figure 1. Full size image. Figure 2. Table 1 Summary of the passage number and chromosomal status of cell lines used for microarray analysis and differentiation experiments. Full size table. Figure 3. Figure 4. Figure 5. Figure 6. Figure 7. Discussion Genetic background is essential for stem cell derivation, particularly in LS conditions. Materials and Methods All products used in the experiments were purchased from Sigma unless otherwise stated. EpiSCs derivation and culture EpiSCs were derived as previously described 21 with some modifications.

References 1. Article PubMed Google Scholar PubMed Google Scholar View author publications. Ethics declarations Competing Interests The authors declare no competing interests.

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Electronic supplementary material. Supplementary Dataset 1. About this article. Cite this article Ghimire, S. Copy to clipboard. Arrastia , Joanna W. Jachowicz , Noah Ollikainen , Matthew S. Curtis , Charlotte Lai , Sofia A. Quinodoz , David A. Selck , Rustem F. Scarfone , Samantha M. Pena , Keith A. Russell , Dean H. Comments By submitting a comment you agree to abide by our Terms and Community Guidelines.

Publish with us For authors Submit manuscript. Search Search articles by subject, keyword or author. Last Update Posted : October 29, See Contacts and Locations. Study Description. This is an exploratory, prospective, multicenter, open-label, single-arm, interventional, Phase IIb study designed to explore the associations over time between clinical assessments, multimodal imaging assessments, aqueous humor AH biomarker patterns, and genetic polymorphisms in participants with diabetic macular edema DME who are treated with faricimab.

FDA Resources. Arms and Interventions. Outcome Measures. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. This inclusion criterion is to be assessed by the central reading center CRC. Decreased visual acuity VA attributable primarily to DME Clear ocular media and adequate pupillary dilation to allow acquisition of good quality retinal images to confirm diagnosis Exclusion Criteria: Currently untreated diabetes mellitus or previously untreated patients who initiated oral or injectable anti-diabetic medication within 3 months prior to Day 1 Any known hypersensitivity to any of the components in the faricimab injection, dilating eye drops, or any of the anesthetics and antimicrobial preparations used by the patient during the study Any major illness or major surgical procedure within 1 month before the Day 1.

One re-screening for this criterion is permitted Any febrile illness within 1 week prior to Day 1. One re-screening for this criterion is permitted Pregnant or breastfeeding, or intending to become pregnant during the study or within 3 months after the final dose of faricimab Renal failure requiring renal transplant, hemodialysis, or peritoneal dialysis within 6 months prior to Day 1 or anticipated to require hemodialysis or peritoneal dialysis at any time during the study Any condition resulting in a compromised immune system that is likely to impact the aqueous humor AH inflammatory biomarkers.

This exclusion criterion is to be assessed by the CRC Any history of or ongoing rubeosis iridis Any panretinal photocoagulation or macular laser photocoagulation treatment received in the study eye prior to the screening visit or expected to be received between the screening visit and Day 1 Any history of treatment with anti-VEGF or any periocular or IVT corticosteroids in the study eye and no such treatment planned for the time between screening and Day 1 Any treatment for dry eye disease in the last month prior to Day 1.

Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. More Information.